Department of Dermatology, University of Gothenburg, S-421 22 Västra Frölunda/Gothenburg, Sweden.
Br J Dermatol. 2009 Sep;161(3):568-76. doi: 10.1111/j.1365-2133.2009.09310.x. Epub 2009 May 26.
Cryosurgery (CS) in the treatment of nonmelanoma skin cancers (NMSCs), especially in the face and on the scalp, has several advantages vs. other methods. Prospectively gathered long-term results after CS are, however, scarce.
To establish long-term results after curettage and CS (CCS) of NMSCs in the face and on the scalp considering complication rate, patient tolerance, cosmetic outcome and rate of recurrence.
Seven hundred and twenty-six patients with 962 face and scalp NMSCs were prospectively followed after CCS (1 week, 3 months, and then annually) during the time period December 1994-September 2008.
Mean/median follow-up time was 42/34 months (range 1 month-14 years). Forty-two of 962 (4.4%) received antibiotics due to clinical, superficial infections. No serious complications were recorded. Ninety-nine per cent of the women and 100% of the men graded the cosmetic outcome as 'good' on a three-level scale, follow-up rate 99%. Fifty-six (14%) women and 78 (23%) men (P = 0.001) developed one or more new NMSCs during the study period. Fourteen of 962 (1.5%) recurrences were recorded, in nine women and five men. An expected recurrence-free rate/cure rate of > 97% after 14 years was calculated (Kaplan-Meier).
CCS in the treatment of NMSCs is expedient and well tolerated, with no major and few minor complications. When performed as in the present study it produces good cosmetic results in virtually all cases, with an anticipated 97% cure rate after 14 years. CCS is thus a highly viable alternative in the treatment of NMSCs in the face and on the scalp.
冷冻手术（CS）在治疗非黑色素瘤皮肤癌（NMSC），特别是在面部和头皮上，与其他方法相比有几个优势。然而，针对 CS 后长期结果的前瞻性研究却很少。
评估在面部和头皮上通过刮除术联合 CS（CCS）治疗 NMSC 的长期结果，包括并发症发生率、患者耐受性、美容效果和复发率。
1994 年 12 月至 2008 年 9 月期间，前瞻性随访了 726 例面部和头皮 NMSC 患者，在 CCS 后（1 周、3 个月，然后每年）进行随访。
平均/中位数随访时间为 42/34 个月（1 个月至 14 年）。962 例中有 42 例（4.4%）因临床或浅表感染而接受抗生素治疗。未记录到严重并发症。99%的女性和 100%的男性按三级评分标准将美容效果评为“良好”，随访率为 99%。56 例（14%）女性和 78 例（23%）男性（P=0.001）在研究期间发生了 1 个或多个新的 NMSC。962 例中有 14 例（1.5%）记录到复发，9 例为女性，5 例为男性。预计 14 年后的无复发生存率/治愈率>97%（Kaplan-Meier）。
CCS 治疗 NMSC 快速且耐受性良好，无重大并发症，仅有少数轻微并发症。按照本研究中的方法进行操作，几乎所有病例的美容效果都很好，预计 14 年后的治愈率为 97%。因此，CCS 是面部和头皮 NMSC 的一种极具潜力的替代治疗方法。
