Department of Clinical & Health Psychology, University of Florida, Gainesville, FL, USA.
Clin Neuropsychol. 2010 Jan;24(1):103-18. doi: 10.1080/13854040903045074. Epub 2009 Jul 23.
Dysnomia is typically assessed during neuropsychological evaluation through visual confrontation naming. Responsive naming to description, however, has been shown to have a more distributed representation in both fMRI and cortical stimulation studies. While naming deficits are common in dementia, the relative sensitivity of visual confrontation versus auditory responsive naming has not been directly investigated. The current study compared visual confrontation naming and auditory responsive naming in a dementia sample of mixed etiologies to examine patterns of performance across these naming tasks. A total of 50 patients with dementia of various etiologies were administered visual confrontation naming and auditory responsive naming tasks using stimuli that were matched in overall word frequency. Patients performed significantly worse on auditory responsive naming than visual confrontation naming. Additionally, patients with mixed Alzheimer's disease/vascular dementia performed more poorly on auditory responsive naming than did patients with probable Alzheimer's disease, although no group differences were seen on the visual confrontation naming task. Auditory responsive naming correlated with a larger number of neuropsychological tests of executive function than did visual confrontation naming. Auditory responsive naming appears to be more sensitive to effects of increased of lesion burden compared to visual confrontation naming. We believe that this reflects more widespread topographical distribution of auditory naming sites within the temporal lobe, but may also reflect the contributions of working memory and cognitive flexibility to performance.
命名障碍通常在神经心理学评估中通过视觉命名来评估。然而，描述性反应命名已在 fMRI 和皮质刺激研究中显示出更广泛的分布表现。虽然命名缺陷在痴呆症中很常见，但视觉命名与听觉反应命名的相对敏感性尚未直接研究。本研究比较了混合病因痴呆症患者的视觉命名和听觉反应命名，以检查这些命名任务的表现模式。共有 50 名患有各种病因的痴呆症患者接受了视觉命名和听觉反应命名任务的测试，测试中使用的刺激在总词汇频率上是匹配的。患者在听觉反应命名方面的表现明显差于视觉命名。此外，患有混合阿尔茨海默病/血管性痴呆的患者在听觉反应命名方面的表现比可能患有阿尔茨海默病的患者差，尽管在视觉命名任务中没有看到任何组间差异。听觉反应命名与更多的执行功能神经心理学测试相关，而视觉命名则不然。与视觉命名相比，听觉反应命名似乎对病变负荷增加的影响更敏感。我们认为这反映了听觉命名部位在颞叶内更广泛的拓扑分布，但也可能反映了工作记忆和认知灵活性对表现的贡献。
