Kruzic J J, Ritchie R O
Department of Mechanical Engineering, Oregon State University, Corvallis, OR 97331, United States.
J Mech Behav Biomed Mater. 2008 Jan;1(1):3-17. doi: 10.1016/j.jmbbm.2007.04.002. Epub 2007 Jun 18.
Gaining a mechanistic understanding of the mechanical properties of mineralized tissues, such as dentin and cortical bone, is important from the perspective of developing a framework for predicting and preventing failure of teeth and whole bones, particularly with regard to understanding the effects of microstructural modifications from factors such as aging, disease, or medical treatments. Accordingly, considerable research efforts have been made to determine the specific mechanisms involved in the fatigue and fracture of mineralized tissues, and to discover how these mechanisms relate to features within the respective microstructures. This article seeks to review the progress that has been made specifically in the area of fatigue, focusing on the research that moves our understanding beyond simple fatigue life (S/N) concepts and instead addresses the separate mechanisms for microdamage initiation, crack propagation, and in the case of bone, repair and remodeling.
从建立预测和预防牙齿及整个骨骼失效的框架这一角度来看，深入了解矿化组织（如牙本质和皮质骨）的力学性能具有重要意义，尤其是在理解衰老、疾病或医学治疗等因素引起的微观结构改变所产生的影响方面。因此，人们付出了大量的研究努力来确定矿化组织疲劳和断裂所涉及的具体机制，并探索这些机制与各自微观结构特征之间的关系。本文旨在回顾在疲劳领域所取得的具体进展，重点关注那些使我们的理解超越简单疲劳寿命（S/N）概念、转而探讨微损伤起始、裂纹扩展以及（就骨骼而言）修复和重塑等不同机制的研究。
