Hashimoto Naoto, Noda Takahiro, Kim Sun-Ju, Sarker Md Zaidul Islam, Yamauchi Hiroaki, Takigawa Shigenobu, Matsuura-Endo Chie, Suzuki Tatsuro, Han Kyu-Ho, Fukushima Michihiro
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido, Japan.
Plant Foods Hum Nutr. 2009 Sep;64(3):193-8. doi: 10.1007/s11130-009-0126-z.
To investigate whether yam improves glucose metabolism, yam-containing diets were given to Wistar rats. In a short-term experiment, fasted-rats were given 1.0 g of a control and 20% yam-containing diets. At 60 min after start of the feeding, glucose level in the yam diet group was lower or tended to be lower than that in the control diet. Insulin levels at 30 min and 60 min were significantly lower than those in the control group. In a long-term experiment, a normal diet (N) or 25% high fat diets with (Y) or without 15% yam powder (HF) were given to rats for 4 weeks. At 4 weeks, in an oral glucose tolerance test, the area under the curve (AUC) of plasma glucose level was higher in the HF group than that in the N group, whereas those in the Y groups did not differ from that in the N group. Glycosylated hemoglobin levels had similar tendency to the AUCs. Plasma leptin levels in the Y groups were significantly higher than that in the N group. In conclusion, yam may contribute to improvement of glucose metabolism. Additionally, we speculated that leptin level is possibly involved in the insulin-response to yam diets.
为研究山药是否能改善葡萄糖代谢，将含山药的饮食喂给Wistar大鼠。在短期实验中，给禁食大鼠分别喂食1.0克对照饮食和含20%山药的饮食。喂食开始后60分钟，山药饮食组的葡萄糖水平低于或趋于低于对照饮食组。30分钟和60分钟时的胰岛素水平显著低于对照组。在长期实验中，给大鼠喂食正常饮食（N）或含15%山药粉（Y）或不含山药粉（HF）的25%高脂肪饮食，持续4周。4周时，在口服葡萄糖耐量试验中，HF组血浆葡萄糖水平的曲线下面积（AUC）高于N组，而Y组与N组无差异。糖化血红蛋白水平与AUC有相似趋势。Y组的血浆瘦素水平显著高于N组。总之，山药可能有助于改善葡萄糖代谢。此外，我们推测瘦素水平可能参与了对山药饮食的胰岛素反应。
