Shishehbor F, Mansoori A, Sarkaki A R, Jalali M T, Latifi S M
Department of Nutrition, Para-Medical School, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Islamic Republic of Iran.
Pak J Biol Sci. 2008 Dec 1;11(23):2634-8. doi: 10.3923/pjbs.2008.2634.2638.
In this study, the effect of apple cider vinegar on Fasting Blood Glucose (FBG), glycated haemoglobin (HbA1c) and lipid profile in normal and diabetic rats was investigated. Diabetes was induced in male Wistar rats (300+/-30 g) by the intraperitoneal injection of streptozotocin (60 mg kg(-1) of body weight). Both normal and diabetic animals were fed with standard animal food containing apple cider vinegar (6% w/w) for 4 weeks. Fasting blood glucose did not change, while HbA1c significantly decreased by apple cider vinegar in diabetic group (p<0.05). In normal rats fed with vinegar, significant reduction of low density lipoprotein-cholesterol (LDL-c) (p<0.005) and significant increase of high density lipoprotein-cholesterol (HDL-c) levels (p<0.005) were observed. Apple cider vinegar also reduced serum triglyceride (TG) levels (p<0.005) and increased HDL-c (p<0.005) in diabetic animals. These results indicate that apple cider vinegar improved the serum lipid profile in normal and diabetic rats by decreasing serum TG, LDL-c and increasing serum HDL-c and may be of great value in managing the diabetic complications.
在本研究中，调查了苹果醋对正常大鼠和糖尿病大鼠空腹血糖（FBG）、糖化血红蛋白（HbA1c）及血脂谱的影响。通过腹腔注射链脲佐菌素（60 mg kg⁻¹体重）诱导雄性Wistar大鼠（300±30 g）患糖尿病。正常和糖尿病动物均喂食含苹果醋（6% w/w）的标准动物饲料4周。空腹血糖未发生变化，而糖尿病组中苹果醋使HbA1c显著降低（p<0.05）。在喂食醋的正常大鼠中，观察到低密度脂蛋白胆固醇（LDL-c）显著降低（p<0.005），高密度脂蛋白胆固醇（HDL-c）水平显著升高（p<0.005）。苹果醋还降低了糖尿病动物的血清甘油三酯（TG）水平（p<0.005）并升高了HDL-c（p<0.005）。这些结果表明，苹果醋通过降低血清TG、LDL-c及升高血清HDL-c改善了正常和糖尿病大鼠的血脂谱，可能在控制糖尿病并发症方面具有重要价值。
