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广泛耐药结核病：古老病原体的新面貌。

Extensively drug-resistant tuberculosis: a new face to an old pathogen.

作者信息

Shenoi Sheela, Friedland Gerald

机构信息

Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06510-8002, USA.

出版信息

Annu Rev Med. 2009;60:307-20. doi: 10.1146/annurev.med.60.053107.103955.

DOI:10.1146/annurev.med.60.053107.103955
PMID:19630575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3013225/
Abstract

The presence and consequences of resistance to drugs used for the treatment of tuberculosis have long been neglected. The recent detection and recognition of widespread multiple-drug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis have raised interest and concern among clinicians and public health authorities globally. In this article, we describe the current global status of drug-resistant tuberculosis. We discuss the development of resistance, current management, and strategies for control.

摘要

用于治疗结核病的药物耐药性的存在及其后果长期以来一直被忽视。近期对广泛存在的多重耐药（MDR）和广泛耐药（XDR）结核病的检测与认识，引起了全球临床医生和公共卫生当局的关注。在本文中，我们描述了耐药结核病的当前全球状况。我们讨论了耐药性的产生、当前的管理方法以及控制策略。

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本文引用的文献

1
Relative numbers of resistant tubercle bacilli in sputa of patients before and during treatment with streptomycin.链霉素治疗前后患者痰液中耐药结核杆菌的相对数量。
Proc Staff Meet Mayo Clin. 1947 Oct 15;22(21):465-73.
2
STREPTOMYCIN treatment of pulmonary tuberculosis.链霉素治疗肺结核。
Br Med J. 1948 Oct 30;2(4582):769-82.
3
Comprehensive treatment of extensively drug-resistant tuberculosis.广泛耐药结核病的综合治疗
N Engl J Med. 2008 Aug 7;359(6):563-74. doi: 10.1056/NEJMoa0800106.
4
Decentralised management of drug-resistant tuberculosis (MDR- and XDR-TB) in South Africa: an alternative model of care.南非耐多药结核病（MDR-TB和XDR-TB）的分散管理：一种替代护理模式。
Int J Tuberc Lung Dis. 2008 Aug;12(8):978-80.
5
Decentralising tuberculosis services from county tuberculosis dispensaries to township hospitals in China: an intervention study.中国结核病服务从县级结核病防治所下放到乡镇医院：一项干预性研究。
Int J Tuberc Lung Dis. 2008 May;12(5):538-47.
6
Trends in tuberculosis--United States, 2007.2007年美国结核病流行趋势
MMWR Morb Mortal Wkly Rep. 2008 Mar 21;57(11):281-5.
7
Rapid molecular screening for multidrug-resistant tuberculosis in a high-volume public health laboratory in South Africa.南非一家大型公共卫生实验室中耐多药结核病的快速分子筛查
Am J Respir Crit Care Med. 2008 Apr 1;177(7):787-92. doi: 10.1164/rccm.200709-1436OC. Epub 2008 Jan 17.
8
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Clin Infect Dis. 2008 Jan 1;46(1):42-9. doi: 10.1086/524017.
9
Evolution of the extensively drug-resistant F15/LAM4/KZN strain of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.南非夸祖鲁 - 纳塔尔省广泛耐药结核分枝杆菌F15/LAM4/KZN菌株的演变
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10
Randomized trials to optimize treatment of multidrug-resistant tuberculosis.优化耐多药结核病治疗的随机试验。
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