Matricardi P M, Bockelbrink A, Grüber C, Keil T, Hamelmann E, Wahn U, Lau S
Department of Pediatric Pneumology and Immunology, Charité University Medical Center, Augustenburger Platz 1, Berlin, Germany.
Allergy. 2009 Jul;64(7):1093-8. doi: 10.1111/j.1398-9995.2009.02055.x.
The development and the quantitative relationship between allergen-specific IgE (S-IgE) responses and total IgE (T-IgE), during childhood and adolescence have not been described and understood in detail. The objective of this study was to describe and compare the longitudinal trends of serum levels of S-IgE and T-IgE during childhood.
We analysed data from participants in the MAS birth cohort study at 2, 5, 7 and 10 years of age (n = 273) and at 1, 3, 5, 6, 7, 10 and 13 years (n = 84). Total-IgE and the overall level of specific-IgE against nine locally relevant airborne and food allergens were determined by FEIA (ImmunoCAP). Allergic rhino-conjunctivitis and asthma were ascertained by questionnaires.
Longitudinal patterns of T-IgE levels from age 1 to 13 years were highly heterogeneous (declining, flat or increasing with different profiles). From 5 years of age, logarithmic (log(10)) transformed values of T-IgE and of S-IgE levels tend to follow a parallel trend, so that their relation remained constant throughout school age. A flat trend of T-IgE vs a constantly increasing trend of T-IgE was associated with a low or, respectively, high rate of wheezing at 13 years of age.
Beginning at the age of 5 years, total serum IgE levels in children from an industrialized country evolved in parallel with overall S-IgE levels. Therefore, variations in T-IgE levels at school age closely reflect variations in overall S-IgE levels. Further studies are required to strengthen the biological and clinical implication of this novel finding.
儿童期和青少年期过敏原特异性IgE（S-IgE）反应与总IgE（T-IgE）之间的发展及其定量关系尚未得到详细描述和理解。本研究的目的是描述和比较儿童期血清S-IgE和T-IgE水平的纵向趋势。
我们分析了MAS出生队列研究中2岁、5岁、7岁和10岁（n = 273）以及1岁、3岁、5岁、6岁、7岁、10岁和13岁（n = 84）参与者的数据。通过FEIA（ImmunoCAP）测定总IgE以及针对九种当地相关空气传播和食物过敏原的特异性IgE的总体水平。通过问卷确定变应性鼻结膜炎和哮喘。
1至13岁T-IgE水平的纵向模式高度异质（下降、平稳或呈不同曲线上升）。从5岁起，T-IgE和S-IgE水平的对数（log(10)）转换值倾向于呈现平行趋势，因此它们在整个学龄期的关系保持不变。13岁时，T-IgE呈平稳趋势与喘息发生率低相关，而T-IgE持续上升趋势则与喘息发生率高相关。
从5岁开始，工业化国家儿童的血清总IgE水平与总体S-IgE水平平行变化。因此，学龄期T-IgE水平的变化密切反映了总体S-IgE水平的变化。需要进一步研究以强化这一新发现的生物学和临床意义。
