Demer Linda L, Tintut Yin
Department of Medicine, BH-307 Center for Health Sciences, Los Angeles, CA 90095-1679, USA.
Curr Osteoporos Rep. 2009 Jul;7(2):42-6. doi: 10.1007/s11914-009-0008-1.
Cardiovascular calcium deposition is associated with osteoporosis through various potential mechanisms involving molecular regulatory factors at the nanoscale level that govern skeletal bone and cardiovascular tissues. In this article, several possible mechanisms linking cardiovascular calcification and osteoporosis are discussed, including aging, tissue-specific responses to chronic inflammation, flow-limiting atherosclerosis of skeletal end arteries causing ischemic abnormalities in metabolism, shared endogenous regulatory factors that affect the two tissues in a reciprocal manner, and changes in a cysteine protease inhibitor, fetuin. Any or all of these factors and phenomena may contribute to the association.
心血管钙沉积与骨质疏松症通过多种潜在机制相关联，这些机制涉及在纳米尺度上调控骨骼和心血管组织的分子调节因子。本文讨论了连接心血管钙化和骨质疏松症的几种可能机制，包括衰老、对慢性炎症的组织特异性反应、骨骼终末动脉的限流性动脉粥样硬化导致代谢中的缺血异常、以相互方式影响这两种组织的共同内源性调节因子，以及一种半胱氨酸蛋白酶抑制剂胎球蛋白的变化。这些因素和现象中的任何一个或全部都可能导致这种关联。
