遗传性癫痫易感性大鼠培养星形胶质细胞中的苯二氮䓬受体。
The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats.
作者信息
Ducis I, Norenberg L O, Norenberg M D
机构信息
Laboratory of Neuropathology, University of Miami/Jackson Memorial Hospital, FL.
出版信息
Brain Res. 1990 Oct 29;531(1-2):318-21. doi: 10.1016/0006-8993(90)90793-b.
Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
在源自遗传性癫痫易感性大鼠和对照大鼠的培养星形胶质细胞中研究了外周型苯二氮䓬（BZD）受体。对来自癫痫易感性大鼠的星形胶质细胞匀浆进行[3H]Ro 5-4864结合的Scatchard分析显示，与对照相比，BZD受体（Bmax）减少了38%。未观察到亲和力（Kd）有显著变化。这些发现表明星形胶质细胞外周型BZD受体可能参与了某些形式的癫痫发作。
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