Roemer Frank W, Guermazi Ali
Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA.
Radiol Clin North Am. 2009 Jul;47(4):633-54. doi: 10.1016/j.rcl.2009.03.005.
Whole-organ semiquantitative (SQ) assessment by expert readers has become a powerful research tool in understanding the natural history of osteoarthritis (OA). SQ morphologic scoring has been applied to observational large cross-sectional and longitudinal epidemiologic studies in addition to interventional clinical trials. In comparison to quantitative and biochemical assessment of cartilage, SQ whole-organ scoring also analyzes additional joint structures that are potentially relevant as surrogate outcome measures for interventional approaches. Resources needed for SQ scoring rely on the MR imaging protocol, image quality, experience of the expert readers, method of documentation, and individual scoring system that is applied. This article discusses the different available OA whole-organ scoring systems, focusing on MR imaging of the knee, and also reviews alternative approaches.
由专业阅片者进行的全器官半定量（SQ）评估已成为理解骨关节炎（OA）自然病程的有力研究工具。除了介入性临床试验外，SQ形态学评分已应用于观察性大型横断面和纵向流行病学研究。与软骨的定量和生化评估相比，SQ全器官评分还分析了其他关节结构，这些结构可能作为介入方法替代结局指标具有相关性。SQ评分所需的资源取决于磁共振成像（MR）协议、图像质量、专业阅片者的经验、记录方法以及所应用的个体评分系统。本文讨论了现有的不同OA全器官评分系统，重点是膝关节的MR成像，同时也回顾了其他方法。
