Department of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil.
Fertil Steril. 2010 Jan;93(1):301-3. doi: 10.1016/j.fertnstert.2009.06.031. Epub 2009 Jul 23.
The objective of this retrospective cohort study was to assess the potential effects of preconceptional short-term exposure to particulate air pollution in a real-world situation on pregnancy outcome in infertile women evaluating the possible role of IVF/embryo transfer treatment on this outcome using women who had conceived naturally for the first time during the same time frame as a matched control group. The study provides evidence for an association between brief exposure to high levels of ambient particulate matter (aerodynamic diameter <or=10 microm) during the preconceptional period and early pregnancy loss, regardless of the method of conception, and showed a 2.6-fold increase in risk of miscarriage, suggesting a threshold instead of a monotonic effect of this exposure on reproductive outcome.
本回顾性队列研究的目的是评估在现实情况下，不孕妇女在受孕前短期接触颗粒性空气污染对妊娠结局的潜在影响，并利用同期首次自然受孕的妇女作为匹配对照组，评估体外受精/胚胎移植治疗对这一结局的可能作用。该研究为受孕前短时间内暴露于高水平环境颗粒物质（空气动力学直径≤10 微米）与早孕丢失之间的关联提供了证据，而与受孕方式无关，并且表明流产风险增加了 2.6 倍，表明这种暴露对生殖结局的影响存在阈值而不是单调递增效应。
