Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94115-1667, USA.
Magn Reson Imaging. 2010 Jan;28(1):8-15. doi: 10.1016/j.mri.2009.05.040. Epub 2009 Jul 23.
A quantitative measure of three-dimensional breast density derived from noncontrast magnetic resonance imaging (MRI) was investigated in 35 women at high-risk for breast cancer. A semiautomatic segmentation tool was used to quantify the total volume of the breast and to separate volumes of fibroglandular and adipose tissue in noncontrast MRI data. The MRI density measure was defined as the ratio of breast fibroglandular volume over total volume of the breast. The overall correlation between MRI and mammographic density measures was R(2)=.67. However the MRI/mammography density correlation was higher in patients with lower breast density (R(2)=.73) than in patients with higher breast density (R(2)=.26). Women with mammographic density higher than 25% exhibited very different magnetic resonance density measures spread over a broad range of values. These results suggest that MRI may provide a volumetric measure more representative of breast composition than mammography, particularly in groups of women with dense breasts. Magnetic resonance imaging density could potentially be quantified and used for a better assessment of breast cancer risk in these populations.
一项针对 35 名乳腺癌高危女性的研究，旨在从非对比磁共振成像（MRI）中得出三维乳房密度的定量测量值。使用半自动分割工具来量化乳房的总体积，并将非对比 MRI 数据中的纤维腺体和脂肪组织体积分开。MRI 密度测量值定义为乳房纤维腺体体积与乳房总体积的比值。MRI 和乳房 X 线照相密度测量值之间的总体相关性为 R(2)=.67。然而，在乳房密度较低的患者中（R(2)=.73），MRI/乳房 X 线照相密度相关性高于乳房密度较高的患者（R(2)=.26）。乳房 X 线照相密度高于 25%的女性表现出非常不同的磁共振密度值，分布在广泛的范围内。这些结果表明，MRI 可能比乳房 X 线照相术提供更能代表乳房成分的体积测量值，特别是在乳房致密的女性群体中。磁共振成像密度可以被定量，并用于更好地评估这些人群的乳腺癌风险。
