State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, PR China.
Brain Res. 2009 Dec 11;1302:256-64. doi: 10.1016/j.brainres.2009.07.030. Epub 2009 Jul 23.
IL-1beta is a potent pro-inflammatory cytokine that regulates neuroinflammation during brain damage. The expression of IL-1beta has been reported to be elevated in the striatum and substantia nigra of patients with Parkinson's disease (PD). Moreover, greater prevalence of PD in men than in women is described previously. Here, by using a sensitive mice model in which the expression of luciferase reporter gene is under the control of human IL-1beta gene promoter, we examined IL-1beta gene expression pattern in vivo after subacute MPTP toxication in old male and female mice and found that MPTP elicited greater dopaminergic toxicity in old male than in female mice. Old male mice showed dramatically elevated luciferase signals in a flexuous manner at early period of time, meanwhile, the changes in female were more moderate. However, no significant difference in astroglial reaction was observed at later time point between sexes. In conclusion, the present study demonstrated that elevated IL-1beta gene expression at early period of time may be in part responsible for the DA neuron susceptibility to MPTP in old male mice.
IL-1β 是一种有效的促炎细胞因子，可在脑损伤期间调节神经炎症。据报道，帕金森病 (PD) 患者纹状体和黑质中的 IL-1β 表达升高。此外，先前已经描述了男性 PD 的患病率高于女性。在这里，我们使用了一种灵敏的小鼠模型，其中荧光素酶报告基因的表达受人类 IL-1β 基因启动子的控制，我们检查了亚急性 MPTP 中毒后老年雄性和雌性小鼠体内的 IL-1β 基因表达模式，发现 MPTP 在老年雄性小鼠中引起了更大的多巴胺能毒性。老年雄性小鼠在早期以弯曲的方式表现出明显升高的荧光素酶信号，而雌性的变化则更为温和。然而，在后期，性别之间的星形胶质细胞反应没有明显差异。总之，本研究表明，早期升高的 IL-1β 基因表达可能部分导致老年雄性小鼠对 MPTP 中 DA 神经元的易感性。
