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[REACH注册研究对内分泌科医生的启示]

[Implications of the REACH registry for endocrinologists].

作者信息

Alonso Guillermo

机构信息

Hospital Universitario San Cecilio, Granada, España.

出版信息

Med Clin (Barc). 2009 Sep;132 Suppl 2:21-4. doi: 10.1016/S0025-7753(09)71748-8.

Abstract

Diabetes mellitus is a major public health problem due to its increasing incidence in the general population and the morbidity and mortality associated with micro- and macrovascular complications. Patients with diabetes have a 2-5-fold increased risk of coronary heart disease, stroke and peripheral artery disease. The REACH registry is the largest observational study in the world designed to assess prognostic and therapeutic data in the population with elevated risk for atherothrombotic events. The results of this study show a high prevalence of obesity, diabetes mellitus and metabolic syndrome in the population with increased cardiovascular risk. Moreover, the data demonstrate that metabolic control of diabetes mellitus is clearly inadequate. Data from the REACH registry show endocrinologists and diabetologists that a multidisciplinary approach is imperative and that adequate management of diabetic patients should include stratification of cardiovascular risk, including assessment of associated conditions such as obesity, hypertension, dyslipidemia, microalbuminuria and smoking.

摘要

糖尿病是一个重大的公共卫生问题,这是由于其在普通人群中的发病率不断上升,以及与微血管和大血管并发症相关的发病率和死亡率所致。糖尿病患者患冠心病、中风和外周动脉疾病的风险增加2至5倍。REACH注册研究是世界上最大的观察性研究,旨在评估动脉粥样硬化血栓形成事件风险升高人群的预后和治疗数据。这项研究的结果显示,在心血管风险增加的人群中,肥胖、糖尿病和代谢综合征的患病率很高。此外,数据表明糖尿病的代谢控制明显不足。REACH注册研究的数据向内分泌科医生和糖尿病专家表明,多学科方法势在必行,糖尿病患者的充分管理应包括心血管风险分层,包括评估肥胖、高血压、血脂异常、微量白蛋白尿和吸烟等相关情况。

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