Wiznitzer Arnon, Mayer Amit, Novack Victor, Sheiner Eyal, Gilutz Harel, Malhotra Atul, Novack Lena
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Am J Obstet Gynecol. 2009 Nov;201(5):482.e1-8. doi: 10.1016/j.ajog.2009.05.032. Epub 2009 Jul 24.
The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.
Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.
Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.
Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
本研究评估了患有和未患有子痫前期和/或妊娠期糖尿病的孕妇在妊娠期间的血脂变化情况。
对9911名无心血管合并症的女性在孕前一年和孕后进行了血脂评估。
妊娠期间血脂水平变化很大，受孕后降至最低点，分娩时达到峰值。与孕前水平相比，总胆固醇水平从164.4毫克/分升升至238.6毫克/分升，甘油三酯（TGs）从92.6毫克/分升升至238.4毫克/分升。1209名女性（12.2%）出现了复合终点（妊娠期糖尿病或子痫前期）。其患病率随TG水平升高而增加——从TG水平低的组（低于根据妊娠月份调整后的第25百分位数）的7.2%增至TG水平高的组（高于第75百分位数）的19.8%，但与高密度脂蛋白水平无关。在多变量分析中，较高的TG水平而非低高密度脂蛋白水平与主要终点相关。
妊娠期间血脂水平变化很大。TG水平异常与妊娠并发症相关。
