Kaida K, Kanzaki M, Morita D, Kamakura K, Motoyoshi K, Hirakawa M, Kusunoki S
Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama-Ken, Japan.
J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1043-6. doi: 10.1136/jnnp.2006.087940. Epub 2006 Apr 13.
Some ganglioside complexes (GSCs) are target antigens for serum antibodies in patients with Guillain-Barré syndrome (GBS). Anti-GSC antibodies may be associated with particular clinical features of GBS.
To investigate antibodies to GSCs in the sera of patients with Miller Fisher syndrome (MFS) characterised by elevation of the IgG anti-GQ1b antibody.
In all, 7 of 12 (58%) consecutive patients with MFS were found to have IgG antibodies to GSCs containing GQ1b, of whom 5 had IgG antibodies to GQ1b-GM1 complex (GQ1b/GM1) and 2 had antibodies to GQ1b/GD1a; 4 of 5 patients without sensory symptoms had anti-GQ1b/GM1 antibodies.
At least three different specificities in MFS-associated antibodies, GQ1b-specific, anti-GQ1b/GM1-positive and anti-GQ1b/GD1a-positive, were observed. In patients with MFS not only GQ1b itself but also clustered epitopes of GSCs, including GQ1b, may be considered to be prime target antigens for serum antibodies. A tendency to escape sensory disturbances is shown by anti-GQ1b/GM1-positive MFS.
一些神经节苷脂复合物（GSCs）是吉兰 - 巴雷综合征（GBS）患者血清抗体的靶抗原。抗GSC抗体可能与GBS的特定临床特征相关。
研究以IgG抗GQ1b抗体升高为特征的米勒费雪综合征（MFS）患者血清中抗GSCs抗体。
连续12例MFS患者中，共有7例（58%）被发现存在针对含GQ1b的GSCs的IgG抗体，其中5例有针对GQ1b - GM1复合物（GQ1b/GM1）的IgG抗体，2例有针对GQ1b/GD1a的抗体；5例无感觉症状的患者中有4例有抗GQ1b/GM1抗体。
观察到MFS相关抗体中至少存在三种不同的特异性，即GQ1b特异性、抗GQ1b/GM1阳性和抗GQ1b/GD1a阳性。在MFS患者中，不仅GQ1b本身，而且包括GQ1b在内的GSCs的聚集表位可能被认为是血清抗体的主要靶抗原。抗GQ1b/GM1阳性的MFS表现出无感觉障碍的倾向。
