Department of Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada.
Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1507-11. doi: 10.1016/j.ijrobp.2009.04.024. Epub 2009 Jul 23.
To explore the relationships (clusters) among the functional interference items in the Brief Pain Inventory (BPI) in patients with bone metastases.
Patients enrolled in the Radiation Therapy Oncology Group (RTOG) 9714 bone metastases study were eligible. Patients were assessed at baseline and 4, 8, and 12 weeks after randomization for the palliative radiotherapy with the BPI, which consists of seven functional items: general activity, mood, walking ability, normal work, relations with others, sleep, and enjoyment of life. Principal component analysis with varimax rotation was used to determine the clusters between the functional items at baseline and the follow-up. Cronbach's alpha was used to determine the consistency and reliability of each cluster at baseline and follow-up.
There were 448 male and 461 female patients, with a median age of 67 years. There were two functional interference clusters at baseline, which accounted for 71% of the total variance. The first cluster (physical interference) included normal work and walking ability, which accounted for 58% of the total variance. The second cluster (psychosocial interference) included relations with others and sleep, which accounted for 13% of the total variance. The Cronbach's alpha statistics were 0.83 and 0.80, respectively. The functional clusters changed at week 12 in responders but persisted through week 12 in nonresponders.
Palliative radiotherapy is effective in reducing bone pain. Functional interference component clusters exist in patients treated for bone metastases. These clusters changed over time in this study, possibly attributable to treatment. Further research is needed to examine these effects.
探讨骨转移患者简明疼痛量表（BPI）中功能干扰项目之间的关系（聚类）。
符合条件的患者为入组放射治疗肿瘤协作组（RTOG）9714 骨转移研究的患者。在随机分组后 4、8 和 12 周时，患者使用 BPI 进行评估，BPI 包括七个功能项目：一般活动、情绪、行走能力、正常工作、与他人的关系、睡眠和生活享受。采用主成分分析和方差极大旋转法确定基线和随访时功能项目之间的聚类。使用克朗巴赫 α 来确定基线和随访时每个聚类的一致性和可靠性。
共有 448 名男性和 461 名女性患者，中位年龄为 67 岁。基线时有两个功能干扰聚类，占总方差的 71%。第一个聚类（身体干扰）包括正常工作和行走能力，占总方差的 58%。第二个聚类（心理社会干扰）包括与他人的关系和睡眠，占总方差的 13%。克朗巴赫 α 统计量分别为 0.83 和 0.80。功能聚类在应答者中在第 12 周发生变化，但在无应答者中持续到第 12 周。
姑息性放疗可有效减轻骨痛。接受骨转移治疗的患者存在功能干扰成分聚类。这些聚类在本研究中随时间发生变化，可能与治疗有关。需要进一步研究以检验这些影响。
