骨转移患者姑息性放疗后的生活质量：文献综述。
Quality of life after palliative radiotherapy in bone metastases: A literature review.
机构信息
Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Bone Oncol. 2014 Nov 18;4(1):24-31. doi: 10.1016/j.jbo.2014.11.001. eCollection 2015 Mar.
OBJECTIVE
To investigate the quality of life (QOL) following palliative radiotherapy for painful bone metastases.
METHODS
A literature search was conducted in OvidSP Medline (1946-Jan Week 4 2014), Embase (1947-Week 5 2014), and the Cochrane Central Register of Controlled Trials (Dec 2013) databases. The search was limited to English. Subject headings and keywords included 'palliative radiation', 'cancer palliative therapy', 'bone metastases', 'quality of life', and 'pain'. All studies (prospective or retrospective) reporting change in QOL before and after palliative radiotherapy for painful bone metastases were included.
RESULTS
Eighteen articles were selected from a total of 1730. The most commonly used tool to evaluate QOL was the Brief Pain Inventory. Seventeen studies collected data prospectively. An improvement in symptoms and functional interference scores following radiotherapy was observed in all studies. The difference in changes in QOL between responders and non responders was inconsistently reported.
CONCLUSION
QOL improves in patients who respond to palliative radiotherapy for painful bone metastases.
目的
调查姑息性放疗治疗骨转移疼痛患者的生活质量（QOL）。
方法
在 OvidSP Medline（1946 年 1 月第 4 周-2014 年 1 月第 4 周）、Embase（1947 年-2014 年第 5 周）和 Cochrane 中央对照试验注册库（2013 年 12 月）数据库中进行文献检索。检索仅限于英文。主题词和关键词包括“姑息性放疗”、“癌症姑息疗法”、“骨转移”、“生活质量”和“疼痛”。纳入所有报告姑息性放疗治疗骨转移疼痛患者 QOL 变化的前瞻性或回顾性研究。
结果
从总共 1730 篇文章中选择了 18 篇。最常用于评估 QOL 的工具是简明疼痛量表。17 项研究前瞻性地收集数据。所有研究均观察到放疗后症状和功能障碍评分改善。对有反应者和无反应者 QOL 变化的差异报道不一致。
结论
对姑息性放疗治疗骨转移疼痛有反应的患者 QOL 改善。
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