因转运RNA切割而倍感压力。
Stressing out over tRNA cleavage.
作者信息
Thompson Debrah M, Parker Roy
机构信息
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.
出版信息
Cell. 2009 Jul 23;138(2):215-9. doi: 10.1016/j.cell.2009.07.001.
PMID:19632169
Abstract
A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new aspect of cellular stress responses, with a potential impact on translation, apoptosis, cancer, and disease progression.
摘要
对压力的一种保守反应涉及核糖核酸酶对细胞质转运RNA（tRNA）的内切核酸酶切割，这些核糖核酸酶通常是分泌型或隔离型的。核糖核酸酶的激活或释放是细胞应激反应中一个引人关注的新方面，对翻译、细胞凋亡、癌症和疾病进展可能产生影响。
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