Xie Chunfeng, Chen Sihong, Wang Chengyuan, Si Wei, Wang Zidan, Luo Qi, Qi Chan
Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Front Cardiovasc Med. 2025 Aug 21;12:1622248. doi: 10.3389/fcvm.2025.1622248. eCollection 2025.
tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs that are generated by cleavage of precursors or mature tRNAs under stress conditions such as hypoxia, oxidative stress and nutrient deficiency. Recent breakthroughs in RNA sequencing technology have revealed their association with cardiovascular diseases (CVDs), including myocardial infarction (MI), atherosclerosis, cardiac hypertrophy, aortic coarctation, and pulmonary arterial hypertension. tsRNAs play important biological functions in these diseases, including the inhibition of apoptosis, epigenetic modification, intercellular signaling mediation, translation, and regulation of gene expression. In addition, tsRNAs show promise as both detectable indicators and intervention targets for CVD. This review examines the biogenesis, classification, and multifaceted functions of tsRNAs in CVD, emphasizing their dual roles as diagnostic tools and therapeutic targets. future research should focus on elucidating tsrna-mediated regulatory networks and developing RNA-based interventions to address unmet needs in cardiovascular medicine.
转运RNA衍生的小RNA（tsRNAs）是一类非编码RNA，在缺氧、氧化应激和营养缺乏等应激条件下，由前体或成熟转运RNA的切割产生。RNA测序技术的最新突破揭示了它们与心血管疾病（CVDs）的关联，包括心肌梗死（MI）、动脉粥样硬化、心脏肥大、主动脉缩窄和肺动脉高压。tsRNAs在这些疾病中发挥着重要的生物学功能，包括抑制细胞凋亡、表观遗传修饰、细胞间信号传导介导、翻译以及基因表达调控。此外，tsRNAs有望成为CVD的可检测指标和干预靶点。本综述探讨了tsRNAs在CVD中的生物发生、分类和多方面功能，强调了它们作为诊断工具和治疗靶点的双重作用。未来的研究应侧重于阐明tsRNA介导的调控网络，并开发基于RNA的干预措施，以满足心血管医学中未满足的需求。
