Fan X
Zhonghua Yi Xue Za Zhi. 1990 Nov;70(11):608-10, 42.
Lipid peroxide (Lpo) of peripheral blood lymphocytes was measured with fluorescent method in 69 cases of hepatitis B and 35 normal subjects. The lymphocyte Lpo in patients with chronic active and severe hepatitis B was much higher than that in the normal subjects (P less than 0.01). Furthermore, the value of lymphocyte Lpo showed negative correlation with the number of peripheral blood lymphocytes (P less than 0.05) and the activity of interleukin 2 (P less than 0.01) in patients with severe hepatitis B. It also showed negative correlation with the latter in cases with chronic active hepatitis B (P less than 0.05). These data suggest that lipid peroxidation of peripheral blood lymphocytes may be one of the causes of immune dysfunction in patients with hepatitis B.
采用荧光法检测了69例乙型肝炎患者及35例正常对照者外周血淋巴细胞脂质过氧化物（Lpo）水平。慢性活动性及重型乙型肝炎患者淋巴细胞Lpo水平显著高于正常对照者（P<0.01）。此外，重型乙型肝炎患者淋巴细胞Lpo水平与外周血淋巴细胞计数（P<0.05）及白细胞介素2活性（P<0.01）呈负相关。慢性活动性乙型肝炎患者淋巴细胞Lpo水平与白细胞介素2活性也呈负相关（P<0.05）。这些数据提示外周血淋巴细胞脂质过氧化可能是乙型肝炎患者免疫功能紊乱的原因之一。
