基因多样性能预测人类健康状况吗？
Does genetic diversity predict health in humans?
作者信息
Lie Hanne C, Simmons Leigh W, Rhodes Gillian
机构信息
School of Psychology, University of Western Australia, Crawley, Western Australia, Australia.
出版信息
PLoS One. 2009 Jul 27;4(7):e6391. doi: 10.1371/journal.pone.0006391.
Genetic diversity, especially at genes important for immune functioning within the Major Histocompatibility Complex (MHC), has been associated with fitness-related traits, including disease resistance, in many species. Recently, genetic diversity has been associated with mate preferences in humans. Here we asked whether these preferences are adaptive in terms of obtaining healthier mates. We investigated whether genetic diversity (heterozygosity and standardized mean d(2)) at MHC and nonMHC microsatellite loci, predicted health in 153 individuals. Individuals with greater allelic diversity (d(2)) at nonMHC loci and at one MHC locus, linked to HLA-DRB1, reported fewer symptoms over a four-month period than individuals with lower d(2). In contrast, there were no associations between MHC or nonMHC heterozygosity and health. NonMHC-d(2) has previously been found to predict male preferences for female faces. Thus, the current findings suggest that nonMHC diversity may play a role in both natural and sexual selection acting on human populations.
遗传多样性，尤其是主要组织相容性复合体（MHC）中对免疫功能重要的基因的遗传多样性，在许多物种中都与包括抗病性在内的与适应性相关的性状有关。最近，遗传多样性与人类的配偶偏好有关。在这里，我们探讨了这些偏好在获得更健康配偶方面是否具有适应性。我们研究了MHC和非MHC微卫星位点的遗传多样性（杂合性和标准化平均d(2)）是否能预测153名个体的健康状况。在非MHC位点以及与HLA-DRB1相关的一个MHC位点上具有更高等位基因多样性（d(2)）的个体，在四个月的时间里报告的症状比d(2)较低的个体更少。相比之下，MHC或非MHC杂合性与健康之间没有关联。此前已发现非MHC-d(2)能预测男性对女性面孔的偏好。因此，目前的研究结果表明，非MHC多样性可能在作用于人类群体的自然选择和性选择中都发挥作用。
Zotero 插件