Li Xue-Juan, Zhang Hong-Yu
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China.
Nat Prod Commun. 2009 Jun;4(6):877-86.
Dementia is becoming one of the biggest threats to human health. However, there is no efficient therapeutic approach so far. Thus, traditional medicines, which have accumulated certain experience in the treatment of dementia, are attracting more and more attention. Indeed, many anti-dementia drugs or drug candidates have been derived from these medicines. In this article, the profile of anti-dementia agents contained in traditional Chinese medicine (TCM) is described. It is indicated that TCM is not only a rich source of acetylcholinesterase inhibitors, but also of great potential to derive other kinds of anti-dementia agents which are either directly associated with ameliorating dementia or have complementary effects. These agents have apparent implications for anti-dementia drug discovery, especially for finding multicomponent anti-dementia drugs.
痴呆症正成为对人类健康的最大威胁之一。然而，迄今为止尚无有效的治疗方法。因此，在痴呆症治疗方面积累了一定经验的传统药物正受到越来越多的关注。事实上，许多抗痴呆药物或候选药物都源自这些药物。本文描述了中药中所含抗痴呆剂的概况。结果表明，中药不仅是乙酰胆碱酯酶抑制剂的丰富来源，而且在衍生其他与改善痴呆症直接相关或具有互补作用的抗痴呆剂方面也具有巨大潜力。这些药剂对发现抗痴呆药物具有明显意义，特别是在寻找多成分抗痴呆药物方面。
