Jain Kewal K
Jain PharmaBiotech, Basel, Switzerland.
Adv Clin Chem. 2009;47:95-119. doi: 10.1016/s0065-2423(09)47004-5.
Molecular diagnostics play an important role in development of personalized medicine and may be termed personalized diagnostics. This chapter shows the role of various diagnostic technologies in personalizing treatment. Besides polymerase chain reaction (PCR), several non-PCR methods, biochips/microarrays, and nanobiotechnologies play an important role. Technologies for biomarkers, single nucleotide polymorphisms (SNPs), and cytogenetics provide basic information for personalized medicine. Finally, integration of diagnostics with therapeutics is an important component of personalized medicine. Future challenges and prospects of personalized diagnostics are discussed.
分子诊断在个性化医疗的发展中发挥着重要作用，可被称为个性化诊断。本章展示了各种诊断技术在个性化治疗中的作用。除了聚合酶链反应（PCR）外，几种非PCR方法、生物芯片/微阵列和纳米生物技术也发挥着重要作用。生物标志物、单核苷酸多态性（SNP）和细胞遗传学技术为个性化医疗提供了基础信息。最后，诊断与治疗的整合是个性化医疗的一个重要组成部分。本文还讨论了个性化诊断的未来挑战与前景。
