Jain PharmaBiotech, Basel, Switzerland.
Mol Diagn Ther. 2010 Jun 1;14(3):141-7. doi: 10.1007/BF03256366.
Molecular diagnostics plays an important role in the development of personalized medicine. Innovative diagnostic technologies that are increasingly utilized in personalizing treatment include novel polymerase chain reaction (PCR), direct molecular analysis without amplification, DNA sequencing, biochips/microarrays, and nanobiotechnologies. Technologies for detection of copy number variations, single nucleotide polymorphisms, and cytogenetic alterations provide basic information for personalized medicine. Molecular diagnostic technologies are used for the detection of biomarkers, which may form the common basis of diagnostics and therapeutics. Finally, integration of diagnostics with therapeutics is an important component of personalized medicine.
分子诊断在个性化医学的发展中起着重要作用。越来越多地用于个性化治疗的创新诊断技术包括新型聚合酶链反应（PCR）、无需扩增的直接分子分析、DNA 测序、生物芯片/微阵列和纳米生物技术。用于检测拷贝数变异、单核苷酸多态性和细胞遗传学改变的技术为个性化医学提供了基础信息。分子诊断技术用于检测生物标志物，这些标志物可能成为诊断和治疗的共同基础。最后，诊断与治疗的结合是个性化医学的一个重要组成部分。
