Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung 401, Taiwan, Republic of China.
J Nat Prod. 2010 Dec 27;73(12):1993-8. doi: 10.1021/np1003627. Epub 2010 Nov 23.
The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM.
本研究对繁缕组变种长果繁缕的根的化学成分进行了研究，从中分离得到了 21 个β-咔啉生物碱，包括 13 个新化合物，即二氢碎叶紫堇碱 III-XIV（1-12）和二氢碎叶紫堇碱 E（13），以及 8 个已知化合物。新化合物的结构是基于光谱数据分析确定的。在所分离的生物碱中，对 5 个化合物进行了抗炎活性测试，检测其对 LPS 处理的 RAW 264.7 细胞中 NO 产生的抑制作用。所有测试的化合物均表现出对 NO 产生的显著抑制作用，IC（50）值范围为 11.3 至 19.3 μM。
