Arfken Cynthia L, Carney Stuart, Boutros Nash N
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 East Jefferson Avenue, Detroit, MI 48207, USA.
Curr Psychiatry Rep. 2009 Aug;11(4):320-3. doi: 10.1007/s11920-009-0046-5.
Psychiatry has lagged behind other specialties in developing diagnostic laboratory tests for the purpose of confirming or ruling out a diagnosis. Biological research into the pathophysiology of psychiatric disorders has, however, yielded some highly replicable abnormalities that have the potential for development into clinically useful diagnostic tests. To achieve this goal, a process for systematic translation must be developed and implemented. Building on our previous work, we review a proposed process using four clearly defined steps. We conclude that biological parameters currently face challenges in their pathways to becoming diagnostic tests because of both the premature release and premature abandonment of tests. Attention to a systematic translation process aided by these principles may help to avoid these problems.
在开发用于确诊或排除诊断的诊断实验室检测方面，精神病学落后于其他专科。然而，对精神障碍病理生理学的生物学研究已经产生了一些高度可重复的异常情况，这些异常情况有可能发展成为临床上有用的诊断检测方法。为了实现这一目标，必须制定并实施一个系统的转化过程。基于我们之前的工作，我们回顾了一个使用四个明确定义步骤的提议过程。我们得出结论，由于检测过早发布和过早放弃，生物学参数目前在成为诊断检测的道路上面临挑战。关注这些原则辅助下的系统转化过程可能有助于避免这些问题。
