de Buys Roessingh Anthony S, Loriot Marie-Hélène, Wiesenauer Chad, Lallier Michel
Department of General Pediatric Surgery, University Hospital, Hôpital Sainte-Justine, Montréal, Quebec, Canada.
J Pediatr Surg. 2009 Aug;44(8):E5-7. doi: 10.1016/j.jpedsurg.2009.04.023.
Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena. The clinical neurologic manifestations of Lambert-Eaton myasthenic syndrome are muscular weakness, sleepiness, absence of reflexes, and dysautonomia. Neurologic manifestations are explained by the induction of an autoimmune response because of the presence of antigens that are expressed by the tumor. Neurologic paraneoplastic disorders may also be the result of toxicity of drugs, coagulopathy, infection, or metabolic diseases. We describe the case of a 13-month-old child with unusual neurologic symptoms because of the presence of an abdominal neuroblastoma.
兰伯特-伊顿肌无力综合征是一种可能揭示原发性肿瘤的副肿瘤综合征。儿童的神经母细胞瘤和成人的小细胞肺癌是由副肿瘤现象揭示或表现出的主要肿瘤。兰伯特-伊顿肌无力综合征的临床神经学表现为肌肉无力、嗜睡、反射消失和自主神经功能障碍。神经学表现是由于肿瘤表达的抗原诱导自身免疫反应所致。神经副肿瘤性疾病也可能是药物毒性、凝血病、感染或代谢性疾病的结果。我们描述了一名13个月大儿童因腹部神经母细胞瘤出现异常神经症状的病例。
