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[从一名患有卵巢癌转移性大网膜肿瘤患者腹水中分离出的高氯酸可溶性糖蛋白的一些化学和血清学特性]

[Some chemical and serological properties of perchloric acid-soluble glycoproteins separated from ascitic fluid of a patient with metastatic omentum tumor from ovarian cancer].

作者信息

Kurihara M, Shimauchi S, Ohyama K, Yamakawa T, Watanabe H, Hirakawa S, Ohkuma S

机构信息

Isehara Research Laboratory, Kanto Chemical Co., Inc., Kanagawa, Japan.

出版信息

Yakugaku Zasshi. 1990 Oct;110(10):783-7. doi: 10.1248/yakushi1947.110.10_783.

Abstract

One mol perchloric acid-soluble fraction (PASF) obtained from ascitic fluid of a patient (blood group B) with metastatic omentum tumor from ovarian cancer was a glycoprotein fraction containing 35.4% carbohydrate and exhibited A, B and Thomsen-Friedenreich (T) activities. This fraction was separated into three fractions, Frs. 1-3, by a gel filtration with Bio-Gel A-1.5 m column. Among these fractions, Fr. 1 which was obtained in a 5.5% yield to PASF, was a glycoprotein fraction with a high molecular weight, 23.3% carbohydrate and A, B and T activities. Other minor fraction, Fr. 2, and the major fraction, Fr. 3, contained 43.2% and 43.9% carbohydrate, but did not show A, B and T activities, respectively.

摘要

从一名患有卵巢癌转移性网膜肿瘤的患者(B血型)腹水中获得的每摩尔高氯酸可溶性组分(PASF)是一种糖蛋白组分,含35.4%的碳水化合物,并表现出A、B和汤姆森 - 弗里德赖希(T)活性。该组分通过使用Bio - Gel A - 1.5m柱进行凝胶过滤分离为三个组分,即组分1 - 3。在这些组分中,以相对于PASF 5.5%的产率获得的组分1是一种高分子量糖蛋白组分,含23.3%的碳水化合物以及A、B和T活性。其他次要组分,即组分2,以及主要组分,即组分3,分别含有43.2%和43.9%的碳水化合物,但均未表现出A、B和T活性。

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