Corre Christophe, Challis Gregory L
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Nat Prod Rep. 2009 Aug;26(8):977-86. doi: 10.1039/b713024b. Epub 2009 May 22.
Analyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.
对植物和微生物基因组序列的分析揭示了许多基因和基因簇，它们编码的蛋白质与那些已知参与结构复杂天然产物生物合成的蛋白质相似。这些基因和基因簇中的许多并未指导其所在生物体中已知代谢产物的产生。其他的则代表了指导已知天然产物生物合成的新基因簇。本文重点介绍了在研究此类基因簇过程中发现的一些新生物合成化学的例子。
