Zhang Yonghong, Chen Jianglei, Wang Jianjun
Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Biomol NMR Assign. 2008 Dec;2(2):207-10. doi: 10.1007/s12104-008-9122-8. Epub 2008 Oct 4.
Apolipoprotein E is an exchangeable apolipoprotein that plays an important role in lipid/lipoprotein metabolism and cardiovascular diseases. Recent evidence indicates that apoE is also critical in several other important biological processes, including Alzheimer's disease, cognitive function, immunoregulation, cell signaling and infectious diseases. Although the X-ray crystal structure of the apoE N-terminal domain was solved in 1991, there is no structure available for the apoE C-terminal domain and full-length apoE. Here we report a complete NMR backbone spectral assignment of lipid-free human apoE.
载脂蛋白E是一种可交换的载脂蛋白，在脂质/脂蛋白代谢和心血管疾病中发挥重要作用。最近的证据表明，载脂蛋白E在其他几个重要的生物学过程中也至关重要，包括阿尔茨海默病、认知功能、免疫调节、细胞信号传导和传染病。尽管载脂蛋白E N端结构域的X射线晶体结构于1991年得到解析，但载脂蛋白E C端结构域和全长载脂蛋白E的结构尚未获得。在此，我们报告了无脂人载脂蛋白E完整的核磁共振主链光谱归属。
