Lutton Cameron, Sugiyama Sadahiro, Wullschleger Martin E, Williams Richard, Campbell Julie H, Crawford Ross, Goss Ben
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Connect Tissue Res. 2009;50(4):256-62. doi: 10.1080/03008200902836057.
Many wounds to both soft and hard tissues heal via the formation of a granulation tissue bed. This bed is supportive of neoangiogenesis and releases proangiogenic, migratory, and proliferative growth factors and cytokines. In this study granulation tissue was grown on an intraperitoneal implant (4 mm diameter, 20 mm length) in a sheep. After 2 weeks, this implant was removed and transplanted into a femoral bone defect (4 mm diameter, 20 mm length). The sheep were sacrificed after 3 months, and the implant site examined using micro-CT and histology. A bone plaque formed adjacent to the implant, only in the presence of the peritoneal granulation tissue. This suggests that the formation of granulation tissue is a relatively conserved response at various locations in the body and its transplantation from one location to another can be used to induce tissue healing. This technique may prove useful as a method of improving physiological response to biomaterials.
许多软组织和硬组织伤口通过形成肉芽组织床来愈合。该床支持新血管生成，并释放促血管生成、迁移和增殖的生长因子及细胞因子。在本研究中，肉芽组织在绵羊的腹腔植入物（直径4毫米，长度20毫米）上生长。2周后，取出该植入物并移植到股骨骨缺损处（直径4毫米，长度20毫米）。3个月后处死绵羊，并使用微型计算机断层扫描（micro-CT）和组织学检查植入部位。仅在存在腹膜肉芽组织的情况下，植入物附近形成了骨斑。这表明肉芽组织的形成是身体不同部位相对保守的反应，并且将其从一个部位移植到另一个部位可用于诱导组织愈合。该技术可能被证明是一种改善对生物材料生理反应的有用方法。
