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[低水平辐射下绵羊外周血细胞中脂质自由基过氧化速率、腺苷酸环化酶活性及质膜对钙离子的通透性]

[Rate of free radical peroxidation of lipids, activity of adenylate cyclase and permeability of plasma membrane for Ca2+ ions in cells of peripheral blood of sheep exposed to low-level radiation].

作者信息

Mirzoev E B, Kobialko V O

出版信息

Radiats Biol Radioecol. 2009 May-Jun;49(3):261-7.

PMID:19637733
Abstract

Chronic exposure of sheep at doses 0.1 and 0.5 Gy resulted in reduced contents of malondialdehyde, of diene and of triene conjugates and alpha-tocopherol with simultaneous increase in the retinol level in blood plasma. In lymphocytes of peripheral blood, the activity of adenylate cyclase was decreased, and in thrombocytes the phase pattern of changes was marked. The enzyme activity in blood cells stimulated by forskolin and prostaglandid E1 was more pronounced. The estimation of the plasma membrane permeability for Ca2+ ions in peripheral blood neutrophils has revealed nonlinear pattern of variations. Erythrocytes the showed increase in passive permeability of plasma membrane for Ca2+ ions.

摘要

绵羊长期暴露于0.1和0.5戈瑞剂量下,导致血浆中丙二醛、二烯和三烯结合物以及α-生育酚含量降低,同时视黄醇水平升高。在外周血淋巴细胞中,腺苷酸环化酶活性降低,而在血小板中变化的阶段模式明显。由福斯高林和前列腺素E1刺激的血细胞中的酶活性更为显著。对外周血中性粒细胞中Ca2+离子的质膜通透性的评估显示出非线性变化模式。红细胞显示出质膜对Ca2+离子的被动通透性增加。

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