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[γ射线照射影响下果蝇翅膀中小镶嵌细胞克隆的高频诱导]

[High frequency induction of small mosaic cell clones in the Drosophila wings under the influence of gamma-irradiation].

作者信息

Dubatolova T D, Kopyl S A, Omel'ianchuk L V

出版信息

Radiats Biol Radioecol. 2009 May-Jun;49(3):360-4.

Abstract

As it was shown earlier in Gonzalez-Gaitan et al., one-cell and two-cells clones (tailing clones) are induced in the Drosophila wings after irradiation and represent a significant portion of clones detected with the use of mwh genetic marker. Our experiments shown that gamma-irradiation occur to be more efficient inductor of such small clones. Earlier small clones were considered as a result of the induced chromosomal aneuploidy of those low proliferating cells. Our data suggest that the small clones descend from the low proliferative cells of non-imaginal disc origin that migrate to the wing imaginal disc at some developmental point.

摘要

正如冈萨雷斯 - 盖坦等人之前所表明的,在果蝇翅膀经辐射后会诱导产生单细胞和双细胞克隆(拖尾克隆),并且这些克隆在使用mwh遗传标记检测到的克隆中占很大一部分。我们的实验表明,γ辐射是诱导此类小克隆更有效的因素。早期,小克隆被认为是那些低增殖细胞诱导染色体非整倍体的结果。我们的数据表明,小克隆源自非成虫盘来源的低增殖细胞,这些细胞在某个发育阶段迁移到翅成虫盘。

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