炭疽致死毒素和水肿毒素的细胞和全身效应。
Cellular and systemic effects of anthrax lethal toxin and edema toxin.
机构信息
Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 33, Room 1W20B, Bethesda, MD 20892, USA.
出版信息
Mol Aspects Med. 2009 Dec;30(6):439-55. doi: 10.1016/j.mam.2009.07.003. Epub 2009 Jul 26.
Abstract
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented.
摘要
炭疽致死毒素 (LT) 和水肿毒素 (ET) 是炭疽的主要毒力因子，可复制与疾病相关的致死性和症状。本文综述了我们目前对动物模型中炭疽毒素作用的理解，以及 LT 在不同细胞中诱导的细胞毒性（坏死和凋亡）。本文还简要回顾了早期历史上关于毒素体内作用的发现，并结合我们目前的知识进行了重新评估。
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本文引用的文献
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The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).心脏是炭疽致死毒素在小鼠体内的早期作用靶点：神经元型一氧化氮合酶（nNOS）的保护作用。
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Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity.炭疽杆菌致死毒素造成的肺上皮损伤是由MKK依赖的细胞骨架完整性丧失所引起的。
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Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.去甲肾上腺素可升高大鼠血压，但不能提高其在炭疽致死毒素作用下的存活率。
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Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages.炭疽致死毒素可触发小鼠巨噬细胞中膜相关炎性小体复合物的形成。
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