Singh Arvind P, Shah Parag P, Ruwali Munindra, Mathur Neeraj, Pant Mohan C, Parmar Devendra
Indian Institute of Toxicology Research, Lucknow, India.
Cancer Invest. 2009 Oct;27(8):869-76. doi: 10.1080/07357900902849657.
A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A12A and CYP1A12C were found to be overrepresented in cases when compared to controls. The HNSCC risk also increased several folds in cases with combination of variant genotypes of CYP1A12A or CYP1A12C with null genotype of glutathione-S-transferase M1 (GSTM1), a phase II enzyme, particularly in cases who were tobacco users (smokers and tobacco chewers), demonstrating the role of gene-gene and gene-environment interactions in the development of HNSCC.
开展了一项病例对照研究，以调查北印度人群中细胞色素P4501A1（CYP1A1）基因多态性与头颈部鳞状细胞癌（HNSCC）之间的关联。与对照组相比，发现CYP1A12A和CYP1A12C的变异基因型在病例中出现的比例过高。对于细胞色素P4501A1（CYP1A1）的变异基因型与II期酶谷胱甘肽-S-转移酶M1（GSTM1）的无效基因型相结合的病例，HNSCC风险也增加了数倍，尤其是在烟草使用者（吸烟者和嚼烟者）中，这表明基因-基因和基因-环境相互作用在HNSCC发生发展中的作用。
