Wang Yadong, Yang Haiyan, Duan Guangcai, Wang Haiyu
Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China; Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, People's Republic of China.
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China.
Onco Targets Ther. 2016 May 17;9:2927-34. doi: 10.2147/OTT.S106264. eCollection 2016.
The aim of this study was to address the association between the Ile462Val polymorphism in the gene encoding cytochrome P450 1A1 (CYP1A1) and the risk of head and neck cancer (HNC).
The Medline/PubMed, EMBASE, and Web of Science databases were searched. The strength of the association was evaluated by calculating the odds ratio (OR) with a 95% confidence interval (CI).
Overall, we observed an increased risk of HNC in patients with the Ile/Val+Val/Val genotype compared to those with the Ile/Ile genotype among the 6,367 cases and 6,395 controls evaluated in the 34 eligible studies, with a pooled OR of 1.284 (95% CI: 1.119-1.473). In addition, we observed an increased risk of HNC in patients with the Ile/Val+Val/Val genotype compared to those with the Ile/Ile genotype in the subgroup analyses (OR =1.362, 95% CI: 1.102-1.685 for laryngeal cancer; OR =1.519, 95% CI: 1.253-1.843 for pharyngeal cancer; OR =1.371, 95% CI: 1.111-1.693 for Asians; and OR =1.329, 95% CI: 1.138-1.551 for patients in studies using hospital-based controls).
This cumulative meta-analysis suggests that the CYP1A1 Ile462Val polymorphism might contribute to the risk of HNC, particularly for pharyngeal cancer and laryngeal cancer.
本研究旨在探讨细胞色素P450 1A1（CYP1A1）基因中Ile462Val多态性与头颈癌（HNC）风险之间的关联。
检索了Medline/PubMed、EMBASE和科学网数据库。通过计算比值比（OR）及95%置信区间（CI）来评估关联强度。
总体而言，在34项符合条件的研究中评估的6367例病例和6395例对照中，我们观察到与Ile/Ile基因型患者相比，Ile/Val+Val/Val基因型患者患HNC的风险增加，合并OR为1.284（95%CI：1.119 - 1.473）。此外，在亚组分析中，我们观察到与Ile/Ile基因型患者相比，Ile/Val+Val/Val基因型患者患HNC的风险增加（喉癌的OR = 1.362，95%CI：1.102 - 1.685；咽癌的OR = 1.519，95%CI：1.253 - 1.843；亚洲人的OR = 1.371，95%CI：1.111 - 1.693；使用医院对照的研究中患者的OR = 1.329，95%CI：1.138 - 1.551）。
这项累积荟萃分析表明，CYP1A1 Ile462Val多态性可能会增加患HNC的风险，尤其是对于咽癌和喉癌。
