Gattás Gilka Jorge Figaro, de Carvalho Marcos Brasilino, Siraque Maria Salete, Curioni Otávio A, Kohler Priscila, Eluf-Neto Jose, Wünsch-Filho Victor
Department of Legal Medicine, Ethics and Occupational Health, School of Medicine, Instituto Oscar Freire, Rua Teodoro Sampaio 115, CEP: 05405-000, São Paulo, SP, Brazil.
Head Neck. 2006 Sep;28(9):819-26. doi: 10.1002/hed.20410.
Alcohol intake and tobacco smoke, in addition to other environmental and genetic factors, have been associated with head and neck cancer. We evaluated the role of metabolic enzyme polymorphisms on the risk of head and neck cancer in a hospital-based case-control study.
CYP1A1MspI, CYP2E1PstI, GSTM1, and GSTT1polymorphisms were evaluated in 103 histologically confirmed head and neck cancer cases and 102 controls by means of polymerase chain reaction-restriction fragment length polymorphism methods.
GSTM1null increased the risk of head and neck cancer (odds ratio [OR], 2.2; 95% confidence interval [95% CI], 1.24-3.79), oral cancer (OR, 2.8; 95% CI, 1.28-5.98), and pharyngeal cancer (OR, 2.2; 95% CI, 1.08-4.63). CYP2E1PstI polymorphism indicated a risk for oral cancer (OR, 3.6; 95% CI, 1.29-11.56). The joint effect of GSTM1 null and CYP1A1 polymorphism increased the risk of head and neck cancer (OR, 2.4; 95% CI, 1.13-5.10).
GSTM1 null alone or associated with CYP1A1 increased the risk of head and neck cancer; the CYP2E1PstI mutated allele increased the risk for only oral cancer.
除其他环境和遗传因素外，酒精摄入和烟草烟雾与头颈癌有关。我们在一项基于医院的病例对照研究中评估了代谢酶多态性在头颈癌风险中的作用。
采用聚合酶链反应-限制性片段长度多态性方法，对103例经组织学确诊的头颈癌病例和102例对照进行CYP1A1MspI、CYP2E1PstI、GSTM1和GSTT1多态性评估。
GSTM1基因缺失增加了头颈癌（优势比[OR]，2.2；95%置信区间[95%CI]，1.24 - 3.79）、口腔癌（OR，2.8；95%CI，1.28 - 5.98）和咽癌（OR，2.2；95%CI，1.08 - 4.63）的风险。CYP2E1PstI多态性表明患口腔癌有风险（OR，3.6；95%CI，1.29 - 11.56）。GSTM1基因缺失和CYP1A1多态性的联合作用增加了头颈癌的风险（OR，2.4；95%CI，1.13 - 5.10）。
单独的GSTM1基因缺失或与CYP1A1相关联会增加头颈癌风险；CYP2E1PstI突变等位基因仅增加口腔癌风险。
