嗜蓝孢孔菌中的两种新型具有细胞抑制和抗真菌活性的（E）-β-甲氧基丙烯酸酯类抗生素——嗜蓝孢孔菌素D和嗜蓝孢孔菌素F (1)。

Strobilurin D and strobilurin F: two new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotics from Cyphellopsis anomala (1).

作者信息

Weber W, Anke T, Bross M, Steglich W

机构信息

Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.

出版信息

Planta Med. 1990 Oct;56(5):446-50. doi: 10.1055/s-2006-961008.

DOI:10.1055/s-2006-961008

PMID:1963952

Abstract

Strobilurin D and strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-beta-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhibit the growth of human and animal cells and a wide variety of fungi. Like strobilurins A and B, the new metabolites are potent inhibitors of respiration.

摘要

嗜球果伞素D和嗜球果伞素F是（E）-β-甲氧基丙烯酸酯类的两种新型细胞生长抑制剂和抗真菌抗生素，它们是从担子菌异常杯伞（Cyphellopsis anomala (Pers. ex Fr.) Sing.）的菌丝体培养物中分离得到的。通过光谱方法阐明了其结构。这些抗生素可抑制人和动物细胞以及多种真菌的生长。与嗜球果伞素A和B一样，这些新的代谢产物是呼吸作用的有效抑制剂。