Dou Chenhui, Wan Yigang, Sun Wei, Zhagn Huilang, Chen Jing, Shui Guangxing, Yao Jian
Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(8):939-43.
The pathomechanisms of the progression of chronic kidney disease (CKD) include glomerulosclerosis, renal interstitial fibrosis and renal arteriosclerosis. Chinese herbal medicine can delay the progression of CKD by ameliorating the harmful factors of these pathological changes, such as podocyte and slit diaphragm injury, nephrotoxicity of proteinuria, hyperactivity of renin-angiotensin-aldosterone system, cytokines over-expression, tubular epithelial myofibroblast transdifferentiation, hyperlipidemia and hypertension.
慢性肾脏病（CKD）进展的病理机制包括肾小球硬化、肾间质纤维化和肾动脉硬化。中药可以通过改善这些病理变化的有害因素来延缓CKD的进展，这些有害因素如足细胞和裂孔隔膜损伤、蛋白尿的肾毒性、肾素 - 血管紧张素 - 醛固酮系统的亢进、细胞因子过度表达、肾小管上皮细胞向肌成纤维细胞转分化、高脂血症和高血压。
