Feng Qing, Wan Yigang, Jiang Chunming, Wang Chaojun, Wei Qingxue, Zhao Qing, Yao Jian
Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China.
Zhongguo Zhong Yao Za Zhi. 2011 May;36(9):1122-8.
In this review,firstly,it has been discussed the mechanisms of Chinese herbal medicine ameliorating glomerulosclerosis and renal interstitial fibrosis during the progression of chronic renal failure (CRF) by improving glomerular hemodynamics turbulence, podocyte injury, transforming growth factor (TGF)-beta over-expression, hyperlipidemia, macrophage infiltration, tubular epithelial myofibroblast transdifferentiation, and nephrotoxicity of proteinuria. Secondly,it has been reported the clinical effects of Chinese herbal medicine improving renal function and some clinical complications in the patients with progressive CRF through various treatments including oral administration or coloclysis of Chinese herbal medicine, oral administration combined with coloclysis of Chinese herbal medicine, and colonic dialysis combined with coloclysis of Chinese herbal medicine. Finally,it has been reviewed the beneficial influences of Chinese herbal medicine on metabolic dysequilibrium of calcium and phosphonium, microinflammatory state, and uremic toxins in patients with uremia.
在本综述中，首先，讨论了中药在慢性肾衰竭（CRF）进展过程中通过改善肾小球血流动力学紊乱、足细胞损伤、转化生长因子（TGF）-β过度表达、高脂血症、巨噬细胞浸润、肾小管上皮细胞向肌成纤维细胞转分化以及蛋白尿的肾毒性来改善肾小球硬化和肾间质纤维化的机制。其次，报道了中药通过口服或中药灌肠、口服联合中药灌肠以及结肠透析联合中药灌肠等多种治疗方法改善进行性CRF患者肾功能及一些临床并发症的临床疗效。最后，综述了中药对尿毒症患者钙磷代谢失衡、微炎症状态和尿毒症毒素的有益影响。
