Chen Jing, Wan Yigang, Bian Rongwen, Gu Liubao, Wang Chaojun, Zhang Huilan, Yao Jian
Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, China.
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):525-30. doi: 10.4268/cjcmm20100427.
The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine.
糖尿病肾病（DN）中肾小球硬化的发病机制被认为与糖代谢紊乱、足细胞损伤、肾内血流动力学异常、促纤维化细胞因子过度表达、氧化应激及炎症反应有关。中药可通过改善这些病理变化的有害因素来延缓DN中肾小球硬化的进展。因此，通过中药治疗有可能延缓DN进展至终末期肾病。
