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中药干预肾间质纤维化的研究进展

Progress of intervention of renal interstitial fibrosis with Chinese traditional herbal medicine.

作者信息

Wei Lian-Bo, Ma Zhi-Gang, Ye Ren-Gao, Chen Bao-Tian, Zhan Sheng-Cai, Huang Huang

机构信息

Department of Traditional Chinese Medicine, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

出版信息

Di Yi Jun Yi Da Xue Xue Bao. 2002 Oct;22(10):946-8.

PMID:12377630
Abstract

This article reviews the current status of progress in the research of renal interstitial fibrosis therapy using traditional Chinese herbal medicine, which exerts its therapeutic effect through inhibiting cytokine expression and fibroblast proliferation, inducing apoptosis of the renal myofibroblasts and other mechanisms.

摘要

本文综述了中药治疗肾间质纤维化的研究进展现状,其通过抑制细胞因子表达和成纤维细胞增殖、诱导肾肌成纤维细胞凋亡等机制发挥治疗作用。

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Traditional Chinese Medicine targeting the TGF-β/Smad signaling pathway as a potential therapeutic strategy for renal fibrosis.以TGF-β/Smad信号通路为靶点的中医药作为肾纤维化潜在治疗策略
Front Pharmacol. 2025 May 20;16:1513329. doi: 10.3389/fphar.2025.1513329. eCollection 2025.
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Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α).大黄素通过过氧化物酶体增殖物激活受体-γ共激活因子-1α(PGC-1α)的介导调节线粒体稳态改善慢性肾脏病肾纤维化。
Eur J Histochem. 2024 May 13;68(2):3917. doi: 10.4081/ejh.2024.3917.