Kimbally-Kaky G, Gombet T, Voumbo Y, Ikama-Méo S, Elenga-Mbola B, Mbika-Cardorelle A, Dilou L, Ekoba J, Nkoua J L, Moyen G, Bouramoué C
Service de cardiologie et médecine interne, CHU de Brazzaville, Congo.
Med Trop (Mars). 2008 Dec;68(6):603-5.
The purpose of this study is to screen for rheumatic heart disease as a basis for treatment of the disease and determination of its prevalence in schoolchildren in Brazzaville, Congo. Surveying was conducted in 4 schools located in suburban districts of Brazzaville from May to June 2005. A cohort of 2250 school children was enrolled by random sampling at 3 levels. Age ranged from 5 to 17 years. The variables recorded were age, sex, socioeconomic status, clinical features, and laboratory findings. Clinical selection was based on cardiac auscultation. Data analysis was performed using the Epi Data 3.1 and Stata 8.2 software packages (differences being considered as significant at p< 0.05). A total of 2232 children underwent testing including 1900 from public schools (boys, 47.5%; girls, 52.5%) and 332 from private schools (boys, 47.3%; girls, 52.7%) (p>0.05). The prevalence of rheumatic heart disease was 3,5 per thousand overall, 3.6 per thousand in children in the low socioeconomic status group, and 3 per thousand in the high socioeconomic status group (p<0.05). The ages of children presenting valvular cardiopathy ranged from 7 and 16-years-old and 75% lived in overcrowded dwellings. One or more previous episodes of strep throat were noted in all cases and had not been treated in 7 out of 8 cases. Valvular disease was significantly correlated with history of strep throat, overcrowded living conditions, and low socioeconomic status (p<0,01). Compliance with prophylactic treatment using benzathyn penicillin was 75% after one month of follow-up and 37.5% after three months.
本研究的目的是筛查风湿性心脏病,为该疾病的治疗及确定其在刚果布拉柴维尔学童中的患病率提供依据。2005年5月至6月,在布拉柴维尔郊区的4所学校开展了调查。通过随机抽样在3个层面选取了2250名学童作为队列研究对象。年龄范围为5至17岁。记录的变量包括年龄、性别、社会经济状况、临床特征和实验室检查结果。临床筛选基于心脏听诊。使用Epi Data 3.1和Stata 8.2软件包进行数据分析(p<0.05时差异被视为具有统计学意义)。共有2232名儿童接受了检测,其中1900名来自公立学校(男孩占47.5%;女孩占52.5%),332名来自私立学校(男孩占47.3%;女孩占52.7%)(p>0.05)。风湿性心脏病的总体患病率为千分之3.5,社会经济地位低的儿童组患病率为千分之3.6,社会经济地位高的儿童组患病率为千分之3(p<0.05)。出现瓣膜性心脏病的儿童年龄在7至16岁之间,75%居住在拥挤的住所。所有病例均有一次或多次既往链球菌性喉炎发作史,8例中有7例未接受治疗。瓣膜性疾病与链球菌性喉炎病史、拥挤的生活条件和低社会经济地位显著相关(p<0.01)。随访1个月后,苄星青霉素预防性治疗的依从率为75%,3个月后为37.5%。