小鼠脑中全长及截短型白细胞介素-18受体α的定位
Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.
作者信息
Alboni Silvia, Cervia Davide, Ross Brendon, Montanari Claudia, Gonzalez Alejandro Sanchez, Sanchez-Alavez Manuel, Marcondes Maria Cecilia Garibaldi, De Vries David, Sugama Shuei, Brunello Nicoletta, Blom Joan, Tascedda Fabio, Conti Bruno
机构信息
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
出版信息
J Neuroimmunol. 2009 Sep 29;214(1-2):43-54. doi: 10.1016/j.jneuroim.2009.06.016. Epub 2009 Jul 28.
Abstract
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
摘要
细胞因子白细胞介素18（IL-18）在生理和病理条件下均可作用于中枢神经系统。其作用通过异二聚体受体IL-18Rαβ发生。为了更好地理解IL-18的中枢效应，我们在小鼠脑中研究了两种IL-18Rα转录本的分布，一种是全长转录本，另一种是缺少假定为诱饵受体的细胞内结构域的同种型。两种同种型主要在全脑的神经元中表达，分布重叠，但也有一些独特的模式。这些数据表明，IL-18可能调节神经元功能，并且其作用可能通过诱饵受体的表达来调节。
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