Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Med Hypotheses. 2009 Dec;73(6):1048-50. doi: 10.1016/j.mehy.2009.06.051. Epub 2009 Jul 28.
Taurine plays various important roles in a large number of physiological and pathological conditions in human body, such as the cytoprotective functions, antioxidant, anti-inflammatory and anti-apoptosis effects. Copper demonstrates a critical effect in the processes of wound healing, including induction of endothelial growth factor, angiogenesis, antimicrobial potency and expression and stabilization of extracellular matrix. Both copper and taurine are effective in accelerating wound healing, but it was rarely reported about the formation of copper complexes of taurine and the effect of the compound in wound healing. Generally speaking, to human body, organic compound could provide a better bioavailability than the inorganic ones. We thus hypothesize that taurine combined with copper would be a new therapeutic candidate for infected wound healing. We name the new compound copper-taurine (CT). Copper-taurine (CT) added into the wound dressings would not only reduce the risk of wound infection, but, more importantly, would stimulate wound repair directly. The sustained release of copper and taurine from the wound dressings into the wound site would together facilitate the wound healing more potently.
牛磺酸在人体的大量生理和病理条件中发挥着各种重要作用，如细胞保护功能、抗氧化、抗炎和抗细胞凋亡作用。铜在伤口愈合过程中起着关键作用，包括诱导内皮生长因子、血管生成、抗菌效力以及细胞外基质的表达和稳定。铜和牛磺酸都能有效地加速伤口愈合，但关于牛磺酸铜复合物的形成及其在伤口愈合中的作用的报道很少。一般来说，有机化合物对人体的生物利用度要优于无机化合物。因此，我们假设牛磺酸与铜结合将成为治疗感染性伤口的新的治疗候选物。我们将这种新的化合物命名为铜牛磺酸（CT）。将铜牛磺酸（CT）添加到伤口敷料中不仅可以降低伤口感染的风险，而且更重要的是可以直接刺激伤口修复。铜和牛磺酸从伤口敷料中持续释放到伤口部位，将共同更有效地促进伤口愈合。
