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开发基于铜的药物、放射性药物和医用材料。

Development of copper based drugs, radiopharmaceuticals and medical materials.

机构信息

Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lodz, Muszyńskiego 1, 90-151, Lodz, Poland.

出版信息

Biometals. 2012 Dec;25(6):1089-112. doi: 10.1007/s10534-012-9578-y. Epub 2012 Aug 23.

DOI:10.1007/s10534-012-9578-y
PMID:22914969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3496555/
Abstract

Copper is one of the most interesting elements for various biomedical applications. Copper compounds show vast array of biological actions, including anti-inflammatory, anti-proliferative, biocidal and other. It also offers a selection of radioisotopes, suitable for nuclear imaging and radiotherapy. Quick progress in nanotechnology opened new possibilities for design of copper based drugs and medical materials. To date, copper has not found many uses in medicine, but number of ongoing research, as well as preclinical and clinical studies, will most likely lead to many novel applications of copper in the near future.

摘要

铜是最有趣的元素之一，适用于各种生物医学应用。铜化合物具有广泛的生物学作用，包括抗炎、抗增殖、杀菌等。它还提供了一系列放射性同位素，适用于核成像和放射治疗。纳米技术的快速发展为设计基于铜的药物和医疗材料开辟了新的可能性。迄今为止，铜在医学上的应用并不多，但目前正在进行的研究，以及临床前和临床研究，很可能在不久的将来导致铜的许多新应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/b4c257222b1d/10534_2012_9578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/3d45c2a90713/10534_2012_9578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/80f575c74c85/10534_2012_9578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/8786022bc224/10534_2012_9578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/749b096feed6/10534_2012_9578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/b4c257222b1d/10534_2012_9578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/3d45c2a90713/10534_2012_9578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/80f575c74c85/10534_2012_9578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/8786022bc224/10534_2012_9578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/749b096feed6/10534_2012_9578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c1f/3496555/b4c257222b1d/10534_2012_9578_Fig5_HTML.jpg

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