Yu Lily M Y, Goda Yukiko
MRC Laboratory for Molecular Cell Biology and MRC Cell Biology Unit, Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Curr Opin Neurobiol. 2009 Jun;19(3):327-35. doi: 10.1016/j.conb.2009.07.002. Epub 2009 Jul 27.
Homeostatic plasticity mechanisms are employed by neurons to alter membrane excitability and synaptic strength to adapt to changes in network activity. Recent studies suggest that homeostatic processes can occur not only on a global scale but also within specific neuronal subcompartments, involving a wide range of molecules and signalling pathways. Here, we review new findings into homeostatic adaptation within dendrites and discuss potential signalling components and mechanisms that may mediate this local form of regulation.
神经元利用稳态可塑性机制来改变膜兴奋性和突触强度，以适应网络活动的变化。最近的研究表明，稳态过程不仅可以在全局范围内发生，也可以在特定的神经元亚区室中发生，涉及广泛的分子和信号通路。在这里，我们综述了树突内稳态适应的新发现，并讨论了可能介导这种局部调节形式的潜在信号成分和机制。
