树突状胞吐作用的机制和功能。
Mechanisms and function of dendritic exocytosis.
机构信息
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Neuron. 2011 Mar 10;69(5):856-75. doi: 10.1016/j.neuron.2011.02.032.
Abstract
Dendritic exocytosis is required for a broad array of neuronal functions including retrograde signaling, neurotransmitter release, synaptic plasticity, and establishment of neuronal morphology. While the details of synaptic vesicle exocytosis from presynaptic terminals have been intensely studied for decades, the mechanisms of dendritic exocytosis are only now emerging. Here we review the molecules and mechanisms of dendritic exocytosis and discuss how exocytosis from dendrites influences neuronal function and circuit plasticity.
摘要
树突出胞作用对于多种神经元功能是必需的，包括逆行信号转导、神经递质释放、突触可塑性和神经元形态的建立。虽然几十年来一直深入研究了突触前末端的突触小泡出胞作用的细节，但树突出胞作用的机制直到现在才开始显现。在这里，我们综述了树突出胞作用的分子和机制，并讨论了树突出胞作用如何影响神经元功能和回路可塑性。
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