Beta-Stim Limited, Caesarea, Israel.
Surg Obes Relat Dis. 2009 Nov-Dec;5(6):692-7. doi: 10.1016/j.soard.2009.05.013. Epub 2009 Jun 11.
Reducing postprandial blood glucose concentrations in diabetic patients might contribute to optimal glycemic control. Gastrointestinal electrical stimulation has been proposed as a novel therapy for both gastrointestinal motility disorders and obesity. The present study investigated the effects and underlying mechanisms of intestinal electrical stimulation (IES) on postprandial blood glucose levels in rats.
Electrical stimulation electrodes were implanted into the duodenal wall of 33 male Sprague-Dawley rats. The blood glucose and insulin levels were measured before and after a glucose tolerance test both with and without electrical stimulation. In addition, the gastric emptying and intestinal flow rates were measured.
IES applied immediately after the glucose tolerance test caused a significant decrease in the rising phase slope and the maximal serum blood glucose level. Additionally, the area under the curve of the blood glucose levels was reduced by approximately 50%. Insulin secretion decreased by 21%. The main reduction in insulin secretion was during the first 30 minutes after the glucose tolerance test. IES also caused a nearly 80% decrease of the gastric emptying rate and a 40% increase in the flow rate of nutrients inside the intestine. The effect was immediate after IES activation and reversible.
These results suggest that IES applied to the duodenum can reduce postprandial blood glucose levels. The possible etiology is the modulating of gastric emptying and intestinal flow rate.
降低糖尿病患者的餐后血糖浓度可能有助于实现最佳血糖控制。胃肠电刺激已被提议作为治疗胃肠动力障碍和肥胖的一种新疗法。本研究旨在探讨肠道电刺激（IES）对大鼠餐后血糖水平的影响及其潜在机制。
将电刺激电极植入 33 只雄性 Sprague-Dawley 大鼠的十二指肠壁。在葡萄糖耐量试验前后，测量有无电刺激时的血糖和胰岛素水平。此外，还测量了胃排空率和肠内流速。
IES 在葡萄糖耐量试验后立即应用，可显著降低血糖升高斜率和最大血清血糖水平。此外，血糖水平的曲线下面积减少了约 50%。胰岛素分泌减少了 21%。胰岛素分泌的主要减少发生在葡萄糖耐量试验后的前 30 分钟内。IES 还导致胃排空率降低近 80%，肠内营养物质流速增加 40%。这种作用在 IES 激活后即刻发生，并具有可逆性。
这些结果表明，IES 应用于十二指肠可降低餐后血糖水平。可能的病因是调节胃排空和肠内流速。
